Chelsea midfielder Danny Drinkwater is expected to be out until the October international break.
Drinkwater was an unused substitute against his former club Leicester last Saturday and missed the midweek Champions League win over Qarabag with a calf problem which means he could be out for four weeks.
Chelsea are likely to rotate their options after making changes for the Qarabag contest, with playmaker Eden Hazard in contention to start for the Blues for the first time this season.
Arsenal are likely to recall a host of first-team regulars for the short trip.
Wenger made nine alterations for the Europa League win over Cologne but the likes of Petr Cech, Mesut Ozil, Laurent Koscielny and Alexandre Lacazette will all return to the squad at Stamford Bridge.
Alexis Sanchez will feature after playing the whole game on Thursday night, where Theo Walcott (calf) hobbled off. Francis Coquelin (hamstring) and Santi Cazorla (ankle) are definitely out.
After winning just four of the previous 16, Chelsea have won their last five home Premier League games against Arsenal, since a 3-5 defeat in October 2011.
The Gunners haven’t kept a Premier League clean sheet at Stamford Bridge in their last 12 visits there, shipping at least twice in each of the eight.
Should Arsenal concede here, it will equal their longest run of away games without a clean sheet against a specific opponent in Premier League history (13 against Liverpool between 1999 and 2012).
Chelsea have scored in 23 successive Premier League games at Stamford Bridge with over half of these (12) seeing them score three or more goals.
Arsenal have lost their first two Premier League away games of the season (0-4 vs Liverpool and 0-1 vs Stoke) – the last time that they lost their first three away games in a league season was 1954-55. Interestingly, this was also the season of Chelsea’s first top-flight title win.
Arsenal last won a Premier League away game against a side that finished in the top six last season, back in January 2015 (2-0 at Man City) – they’ve since lost eight and drawn five of their 13 matches on the road against these clubs.
It’s all about the first goal. If Arsenal score first you will watch and think ‘wow, they look decent’. They will be confident and they have good players who look decent when they are winning.
But when they are losing too many of them just go completely and utterly missing. The shape goes out of the window and if they let in the first goal it could be anything. People are saying to me ‘what a good result against Bournemouth’ but if you could have handpicked any team to play last week it was Bournemouth.